PHOENIX (AP) — Arizona took center stage in the national immigration debate Tuesday as Homeland Security Secretary Janet Napolitano toured the state’s border with Mexico and Sen. John McCain defended his proposed immigration overhaul to an angry crowd in suburban Phoenix.

The presence of the top officials is the latest sign that Arizona will play a prominent role in the immigration debate as President Barack Obama looks to make it a signature issue of his second term.

Napolitano toured the border near Nogales with the highest-ranking official at U.S. Customs and Border Protection, the incoming chairman of the Senate’s homeland security committee and an Arizona congressman. Napolitano, Arizona’s former governor, said afterward that comprehensive immigration reform will strengthen the nation’s border against criminals and other threats.

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