Concerns that interest rates will rise to dampen the economic recovery sent the markets tumbling to a lower close with the Dow plunging 173 points to 8300. Nasdaq dropped 19 points to 1731.

On the upside

Lazard Capital Markets analyst Dr. Sean Lavin upgraded Sequenom (Nasdaq: SQNM) citing the company's attractive stock price.

Angiotech Pharmaceuticals (Nasdaq: ANPI) and Boston Scientific (NYSE: BSX) received approval from the Food and Drug Administration for their next generation TAXUS Liberte Atom stent system.

Coeur d'Alene Mines (NYSE: CDE) completed its 1-for-10 reverse stock split .

On the downside

Delta Air Lines (NYSE: DAL) limited its plans to charge $50 for a second checked bag on all international flights to travel only between the United States and Europe.
Goodyear Tire & Rubber (NYSE: GT) will no longer produce consumer tires at its Amiens, France plant.
US Airways (NYSE: LCC) will raise capital by doubling the number of shares.

In the broad market, advancing issues outpaced decliners by a margin of more than 2 to 1 on the NYSE by nearly the same on Nasdaq. The Russell 2000 which tracks small cap stocks tumbled 10 points to 489.